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ben-AZ-e-pril hye-droe-KLOR-ide, hye-droe-klor-oh-THYE-a-zide

Oral route(Tablet)

When used in pregnancy, ACE inhibitors can cause injury and even death to the developing fetus. When pregnancy is detected, benazepril hydrochloride/hydrochlorothiazide should be discontinued as soon as possible .

Commonly used brand name(s)

In the U.S.

Lotensin HCT

Available Dosage Forms:

Tablet

Therapeutic Class: ACE Inhibitor/Thiazide Combination

Pharmacologic Class: Benazepril

Chemical Class: Thiazide

Uses For benazepril and hydrochlorothiazide

Benazepril and hydrochlorothiazide is a combination of medicines that is used to treat high blood pressure (hypertension). High blood pressure adds to the workload of the heart and arteries. If it continues for a long time, the heart and arteries may not function properly. This can damage the blood vessels of the brain, heart, and kidneys, resulting in a stroke, heart failure, or kidney failure. High blood pressure may also increase the risk of heart attacks. These problems may be less likely to occur if blood pressure is controlled.

Benazepril is an angiotensin-converting enzyme (ACE) inhibitor. It works by blocking a substance in the body that causes blood vessels to tighten. As a result, benazepril relaxes the blood vessels. This lowers blood pressure and increase the supply of blood and oxygen to the heart.

Hydrochlorothiazide is a thiazide diuretic (water pill). It reduces the amount of water in the body by increasing the flow of urine, which helps lower the blood pressure.

benazepril and hydrochlorothiazide is available only with your doctor's prescription.

Before Using benazepril and hydrochlorothiazide

In deciding to use a medicine, the risks of taking the medicine must be weighed against the good it will do. This is a decision you and your doctor will make. For benazepril and hydrochlorothiazide, the following should be considered:

Allergies

Tell your doctor if you have ever had any unusual or allergic reaction to benazepril and hydrochlorothiazide or any other medicines. Also tell your health care professional if you have any other types of allergies, such as to foods, dyes, preservatives, or animals. For non-prescription products, read the label or package ingredients carefully.

Pediatric

Appropriate studies have not been performed on the relationship of age to the effects of benazepril and hydrochlorothiazide combination in the pediatric population. Safety and efficacy have not been established.

Geriatric

Appropriate studies performed to date have not demonstrated geriatric-specific problems that would limit the usefulness of benazepril and hydrochlorothiazide combination in the elderly. However, elderly patients are more likely to have age-related kidney problems, which may require an adjustment in the dose for patients receiving benazepril and hydrochlorothiazide combination.

Pregnancy

	Pregnancy Category	Explanation
All Trimesters	D	Studies in pregnant women have demonstrated a risk to the fetus. However, the benefits of therapy in a life threatening situation or a serious disease, may outweigh the potential risk.

Breast Feeding

There are no adequate studies in women for determining infant risk when using this medication during breastfeeding. Weigh the potential benefits against the potential risks before taking this medication while breastfeeding.

Interactions with Medicines

Although certain medicines should not be used together at all, in other cases two different medicines may be used together even if an interaction might occur. In these cases, your doctor may want to change the dose, or other precautions may be necessary. When you are taking benazepril and hydrochlorothiazide, it is especially important that your healthcare professional know if you are taking any of the medicines listed below. The following interactions have been selected on the basis of their potential significance and are not necessarily all-inclusive.

Using benazepril and hydrochlorothiazide with any of the following medicines is not recommended. Your doctor may decide not to treat you with this medication or change some of the other medicines you take.

Dofetilide

Using benazepril and hydrochlorothiazide with any of the following medicines is usually not recommended, but may be required in some cases. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Acetyldigoxin

Alteplase, Recombinant

Amiloride

Arsenic Trioxide

Azathioprine

Azilsartan Medoxomil

Candesartan Cilexetil

Canrenoate

Deslanoside

Digitalis

Digitoxin

Digoxin

Droperidol

Eplerenone

Eprosartan

Flecainide

Ketanserin

Levomethadyl

Lithium

Losartan

Metildigoxin

Olmesartan Medoxomil

Ouabain

Potassium

Proscillaridin

Sotalol

Spironolactone

Telmisartan

Triamterene

Valsartan

Using benazepril and hydrochlorothiazide with any of the following medicines may cause an increased risk of certain side effects, but using both drugs may be the best treatment for you. If both medicines are prescribed together, your doctor may change the dose or how often you use one or both of the medicines.

Aceclofenac

Acemetacin

Alacepril

Alclofenac

Aliskiren

Apazone

Aspirin

Azosemide

Bemetizide

Benazepril

Bendroflumethiazide

Benoxaprofen

Benzthiazide

Bepridil

Bromfenac

Bufexamac

Bumetanide

Bupivacaine

Buthiazide

Capsaicin

Captopril

Carbamazepine

Carprofen

Celecoxib

Chlorothiazide

Chlorpropamide

Chlorthalidone

Cholestyramine

Cilazapril

Clometacin

Clonixin

Clopamide

Cyclopenthiazide

Cyclophosphamide

Cyclothiazide

Delapril

Dexketoprofen

Diclofenac

Diflunisal

Dipyrone

Droxicam

Enalaprilat

Enalapril Maleate

Ethacrynic Acid

Etodolac

Etofenamate

Felbinac

Fenbufen

Fenoprofen

Fentiazac

Floctafenine

Flufenamic Acid

Flurbiprofen

Fosinopril

Furosemide

Ginkgo

Glipizide

Gold Sodium Thiomalate

Gossypol

Hydrochlorothiazide

Hydroflumethiazide

Ibuprofen

Ibuprofen Lysine

Imidapril

Indapamide

Indomethacin

Indoprofen

Isoxicam

Ketoprofen

Ketorolac

Licorice

Lisinopril

Lithium

Lornoxicam

Magnesium Salicylate

Meclofenamate

Mefenamic Acid

Meloxicam

Methyclothiazide

Metolazone

Moexipril

Nabumetone

Naproxen

Nepafenac

Nesiritide

Niflumic Acid

Nimesulide

Oxaprozin

Oxyphenbutazone

Pentopril

Perindopril

Phenylbutazone

Pirazolac

Piretanide

Piroxicam

Pirprofen

Polythiazide

Propyphenazone

Proquazone

Quinapril

Quinethazone

Ramipril

Salicylic Acid

Salsalate

Spirapril

Sulindac

Suprofen

Temocapril

Tenidap

Tenoxicam

Tiaprofenic Acid

Tolmetin

Topiramate

Torsemide

Trandolapril

Trichlormethiazide

Xipamide

Zofenopril

Zomepirac

Interactions with Food/Tobacco/Alcohol

Certain medicines should not be used at or around the time of eating food or eating certain types of food since interactions may occur. Using alcohol or tobacco with certain medicines may also cause interactions to occur. Discuss with your healthcare professional the use of your medicine with food, alcohol, or tobacco.

Proper Use of benazepril and hydrochlorothiazide

benazepril and hydrochlorothiazide should not be the first medicine you use to treat your condition. It is meant to be used only after you have tried other medicines that have not worked or have caused unwanted side effects.

In addition to the use of benazepril and hydrochlorothiazide, treatment for your high blood pressure may include weight control and a change in the types of foods you eat, especially foods high in sodium (salt). Your doctor will tell you which of these are most important for you. You should check with your doctor before changing your diet.

Many patients who have high blood pressure will not notice any signs of the problem. In fact, many may feel normal. It is very important that you take your medicine exactly as directed and that you keep your appointments with your doctor even if you feel well.

Remember that benazepril and hydrochlorothiazide will not cure your high blood pressure, but it does help control it. You must continue to take it as directed if you expect to lower your blood pressure and keep it down. You may have to take high blood pressure medicine for the rest of your life. If high blood pressure is not treated, it can cause serious problems such as heart failure, blood vessel disease, stroke, or kidney disease.

Dosing

The dose of benazepril and hydrochlorothiazide will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of benazepril and hydrochlorothiazide. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

For oral dosage form (tablets):
- For high blood pressure:
  - Adults—One tablet containing 5 milligrams (mg) of benazepril and 6.25 mg of hydrochlorothiazide once a day. Your doctor may increase your dose as needed.
  - Children—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of benazepril and hydrochlorothiazide, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Precautions While Using benazepril and hydrochlorothiazide

It is very important that your doctor check your progress at regular visits to make sure benazepril and hydrochlorothiazide is working properly. Blood and urine tests may be needed to check for unwanted effects.

Using benazepril and hydrochlorothiazide while you are pregnant (especially in your second or third trimester) can harm your unborn baby. Use an effective form of birth control to keep from getting pregnant. If you think you have become pregnant while using benazepril and hydrochlorothiazide, tell your doctor right away.

benazepril and hydrochlorothiazide may cause serious allergic reactions including anaphylaxis. Anaphylaxis can be life-threatening and requires immediate medical attention. Call your doctor right away if you have a rash; itching; hoarseness; trouble breathing; trouble swallowing; or any swelling of your hands, face, lips, tongue, or throat while you are using benazepril and hydrochlorothiazide.

Stop using benazepril and hydrochlorothiazide and check with your doctor right away if you have a strong stomach pain (with or without nausea or vomiting). This could be a symptom of a condition called intestinal angioedema.

Dizziness, lightheadedness, or fainting may occur after the first dose, especially if you have been taking a diuretic (water pill). Make sure you know how you react to the medicine before you drive, use machines, or do other things that could be dangerous if you are dizzy or not alert.

Check with your doctor right away if you become sick while taking benazepril and hydrochlorothiazide, especially with severe or continuing nausea, vomiting, or diarrhea. These conditions may cause you to lose too much water or salt which may cause low blood pressure.

Check with your doctor if you experience dizziness, fainting, confusion, muscle pain, weakness, and/or a fast heartbeat. Use extra care if you exercise or if the weather is hot. Heavy sweating can cause dehydration (loss of too much water) or electrolyte imbalances (loss of sodium in the body).

Check with your doctor immediately if you have any signs of fever, chills, or sore throat. These could be symptoms of an infection resulting from low white blood cells.

benazepril and hydrochlorothiazide may affect blood sugar levels. If you notice a change in the results of your blood or urine sugar tests, or if you have any questions, check with your doctor.

Liver problems may occur while you are using benazepril and hydrochlorothiazide. Stop using benazepril and hydrochlorothiazide and check with your doctor right away if you are having more than one of these symptoms: abdominal pain or tenderness; clay-colored stools; dark urine; decreased appetite; fever; headache; itching; loss of appetite; nausea and vomiting; skin rash; swelling of the feet or lower legs; unusual tiredness or weakness; or yellow eyes or skin.

Stop using benazepril and hydrochlorothiazide and check with your doctor immediately if blurred vision, difficulty in reading, eye pain, or any other change in vision occurs during or after treatment. This could be a sign of a serious eye problem. Your doctor will want you to have your eyes checked by an ophthalmologist (eye doctor).

Hyperkalemia (high potassium in the blood) may occur while you are using benazepril and hydrochlorothiazide. Check with your doctor right away if you have the following symptoms: abdominal or stomach pain; confusion; difficulty with breathing; irregular heartbeat; nausea or vomiting; nervousness; numbness or tingling in the hands, feet, or lips; shortness of breath; or weakness or heaviness of the legs.

benazepril and hydrochlorothiazide may increase the amount of potassium in your blood. Do not use salt substitutes containing potassium without first checking with your doctor.

Make sure any doctor or dentist who treats you knows that you are using benazepril and hydrochlorothiazide. You may need to stop using benazepril and hydrochlorothiazide several days before having surgery or medical tests.

The risk of a serious allergic reaction involving swelling of the face, mouth, hands, or feet may be increased in black patients.

Do not take other medicines unless they have been discussed with your doctor. This includes over-the-counter (nonprescription) medicines for appetite control, asthma, colds, cough, hay fever, or sinus problems, since they may tend to increase your blood pressure.

benazepril and hydrochlorothiazide Side Effects

Along with its needed effects, a medicine may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur:

Less common

Blurred vision

confusion

decreased urination

dizziness, faintness, or lightheadedness when getting up suddenly from a lying or sitting position

dry mouth

fast, slow, or irregular heartbeat

muscle cramps or pain

numbness, tingling, pain, or weakness in the hands or feet

rapid breathing

seizures

sunken eyes

sweating

thirst

trembling

unusual tiredness or weakness

weakness and heaviness of the legs

wrinkled skin

Some side effects may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

Less common

Cough

decreased interest in sexual intercourse

excessive muscle tone

feeling of constant movement of self or surroundings

inability to have or keep an erection

loss in sexual ability, desire, drive, or performance

muscle stiffness

muscle tension or tightness

nausea

sensation of spinning

sleepiness or unusual drowsiness

Other side effects not listed may also occur in some patients. If you notice any other effects, check with your healthcare professional.

Call your doctor for medical advice about side effects. You may report side effects to the FDA at 1-800-FDA-1088.

See also: benazepril and hydrochlorothiazide side effects (in more detail)

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Tuesday, May 10, 2011

benazepril and hydrochlorothiazide